We demonstrate that ligand binding can be used to induce the formation of triplex structures
that would not otherwise form. Specifically, we show that binding of berenil or 4', 6-diamidino …

A, G, C, T) with DNA fragments containing the sequences AsXAs' Ts-YT8 (X= G, C, T; Y= C,
G, A) by DNase I footprinting. The ligands form a series of quinoline derivatives with an …

The changes inbinding free energies due to cooperativity for oligodeoxyribonucleotides
bound to adjacent sites by triple helix formation havebeen determined by quantitative affinity …

The formation of intermolecular DNA triple helices offers the possibility of designing
compounds with extensive sequence recognition properties which may be useful as …

Recognition of B-DNA by oligonucleotides that form triple helices is a unique method to
specifically recognize sequences of double-stranded DNA. Recently, some significant …

Oligonucleotides that form a triple helix with duplex DNA offer a novel way to site specifically
regulate gene expression in vivo. Triple helices formed by homopyrimidine oligomers …

Oligonucleotides are capable of binding to regions of double helical DNA throughthe
formation of localized triple helical (triplex) structures. 1 Recently, this recognition process …

Triple-helical nucleic acids are formed by binding an oligonucleotide within the major
groove of duplex DNA. These complexes offer the possibility of designing oligonucleotides …

Oligonucleotide directed triple helix formation allows the sequence-specific recognition of
the major groove of double-helical DNA. Recently synthesized base analogs …

There has been considerable interest in the stability and specificity of recognition in triplexes
consisting of both RNA and DNA strands. Biologically important triplexes could be …