The renin-angiotensin system is normally subject to servo control mechanisms that suppress
plasma renin levels in response to increased blood pressure and increase plasma renin …

The renin-angiotensin system plays a major role in the regulation of blood pressure and
electrolyte homeostasis in mammals. In this study, we subjected transgenic mice containing …

To create physiological models of the human renin-angiotensin system in transgenic
animals, the component genes should be expressed in the correct tissues and cells and …

We examined the effect of chronic human renin infusion and human renin inhibition on
blood pressure in a unique transgenic rat model. We infused incremental doses of human …

To examine the utility of rats transgenic for human angiotensinogen in the study of human
renin-induced hypertension, we first developed assays to measure both the human and rat …

We previously reported the generation of transgenic mice containing the entire human renin
gene with a 900-bp promoter. To determine whether all the required elements for …

We developed a model of spontaneously high human renin hypertension in the rat by
producing two transgenic strains, one for human angiotensinogen with the endogenous …

Transgenic rats carrying the murine Ren-2 gene represent a monogenetic model of
hypertension characterized by low plasma renin and high extrarenal expression of the …

A reaction between enzyme renin and its only natural substrate angiotensinogen is the initial
and rate-limiting step for producing a potent vasoconstrictor angiotensin II as the final …

Angiotensinogen, the precursor of a vasoactive octapeptide angiotensin II, is the only known
natural substrate of renin, and its reaction exhibits strict species specificity and is the rate …