Study design. A prospective, randomized experimental research. Objective. To evaluate the
short-and long-term neuroprotective effects of minocycline on the secondary injury process …

We examined the effects of minocycline, an anti-inflammatory drug, on functional recovery
following spinal cord injury (SCI). Rats received a mild, weight-drop contusion injury to the …

This study was initiated due to an NIH “Facilities of Research—Spinal Cord Injury” contract
to support independent replication of published studies that could be considered for a …

Minocycline (MC), a second-generation tetracycline and anti-inflammatory agent reportedly
provides neuroprotection following CNS injury. The objective of this study was to examine …

Acute spinal cord injury (SCI) produces tissue damage that continues to evolve days and
weeks after the initial insult, with corresponding functional impairments. Reducing the extent …

METHODS In this human pilot study, patients presenting within 12 hours of nonpenetrating
traumatic SCI were randomized in a double blind fashion to intravenous minocycline (200 …

Spinal cord injury (SCI) is known as a debilitating condition which usually occurs due to
traumas to the spine. However, the injury could also occur during clinical interventions such …

Background The effects of minocycline on neuronal injury after spinal cord injury (SCI) are
limited and controversial. Therefore we aimed to investigate the protective effects of …

Study Design. A prospective, randomized laboratory investigation. Objective. To investigate
whether administration of minocycline attenuates hind-limb motor dysfunction and gray and …

Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline.
Animal studies and early clinical trials support its use in several neurological diseases. In …