Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines

JD Kisiday, DD Frisbie, CW McIlwraith… - … Engineering Part A, 2009 - liebertpub.com
The objective of this study was to evaluate the effect of dynamic compression on
mesenchymal stem cell (MSC) chondrogenesis. Dynamic compression was applied to …

Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds

P Angele, D Schumann, M Angele, B Kinner… - …, 2004 - content.iospress.com
The effects of cyclic, mechanical compression on human bone marrow‐derived
mesenchymal progenitor cells undergoing chondrogenic differentiation were examined in …

Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells

SD Thorpe, CT Buckley, T Vinardell, FJ O'Brien… - Biochemical and …, 2008 - Elsevier
The objective of this study was to investigate the influence of dynamic compressive loading
on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-β3. Isolated …

Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression

MG Haugh, EG Meyer, SD Thorpe… - … Engineering Part A, 2011 - liebertpub.com
Various forms of mechanical stimulation have been shown to enhance chondrogenesis of
mesenchymal stem cells (MSCs). However, the response of MSCs undergoing …

Differential response of adult and embryonic mesenchymal progenitor cells to mechanical compression in hydrogels

V Terraciano, N Hwang, L Moroni, HB Park, Z Zhang… - Stem …, 2007 - academic.oup.com
Cells in the musculoskeletal system can respond to mechanical stimuli, supporting tissue
homeostasis and remodeling. Recent studies have suggested that mechanical stimulation …

[HTML][HTML] Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogels

AH Huang, MJ Farrell, M Kim… - European cells & …, 2010 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are an attractive cell source for cartilage tissue engineering
given their ability to undergo chondrogenesis in 3D culture systems. Mechanical forces play …

The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation

SD Thorpe, CT Buckley, T Vinardell, FJ O'Brien… - Annals of biomedical …, 2010 - Springer
The objective of this study was to investigate the hypothesis that the application of dynamic
compression following transforming growth factor-β3 (TGF-β3) induced differentiation will …

Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells

JJ Campbell, DA Lee, DL Bader - Biorheology, 2006 - content.iospress.com
This study tests the hypothesis that dynamic compressive strain selectively enhances
chondrogenic differentiation by human mesenchymal stem cells (MSCs). Primary MSCs …

Dynamic compression modulates chondrocyte proliferation and matrix biosynthesis in chitosan/gelatin scaffolds

PY Wang, HH Chow, JY Lai, HL Liu… - Journal of Biomedical …, 2009 - Wiley Online Library
It is well‐documented that dynamical compression stimulates biosynthesis of extracellular
biomacromolecules in cartilage explant or in chondrocyte/hydrogel systems. The object of …

Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression

EG Meyer, CT Buckley, SD Thorpe, DJ Kelly - Journal of biomechanics, 2010 - Elsevier
During fracture healing and microfracture treatment of cartilage defects mesenchymal stem
cells (MSCs) infiltrate the wound site, proliferate extensively and differentiate along a …