CLEC5A mediates Zika virus-induced testicular damage

HW Wang, HH Li, SC Wu, CK Tang, HY Yu… - Journal of Biomedical …, 2023 - Springer
Background Zika virus (ZIKV) infection is clinically known to induce testicular swelling,
termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain …

CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice

RK Campos, Y Liang, SR Azar, J Ly, VN Camargos… - npj Viruses, 2024 - nature.com
Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters
and causes testicular damage in mouse models. The involvement of individual immune cells …

Immunocompetent mouse models revealed that S100A4+ monocytes/macrophages facilitate long-term Zika virus infection in the testes

W Yang, C Zhang, LB Liu, ZZ Bian… - Emerging Microbes & …, 2024 - Taylor & Francis
During its global epidemic, Zika virus (ZIKV) attracted widespread attention due to its link
with various severe neurological symptoms and potential harm to male fertility. However, the …

Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation

W Yang, LB Liu, FL Liu, YH Wu, ZD Zhen… - Nature …, 2023 - nature.com
Zika virus (ZIKV) is a potential threat to male reproductive health but the mechanisms
underlying its influence on testes during ZIKV infection remain obscure. To address this …

Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice

Z Sheng, N Gao, D Fan, N Wu, Y Zhang… - PLoS Neglected …, 2021 - journals.plos.org
Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to
infertility in mice; however, the infection in the epididymis, another important organ of male …

IP-10 and CXCR3 signaling inhibit Zika virus replication in human prostate cells

JL Spencer Clinton, LL Tran, MB Vogt, DR Rowley… - Plos one, 2020 - journals.plos.org
Our previous studies have shown that Zika virus (ZIKV) replicates in human prostate cells,
suggesting that the prostate may serve as a long-term reservoir for virus transmission. Here …

Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier

L Hui, Y Nie, S Li, M Guo, W Yang, R Huang… - PLoS …, 2020 - journals.plos.org
Zika virus (ZIKV) is a unique flavivirus with high tropism to the testes. ZIKV can persist in
human semen for months and can cause testicular damage in male mice. However, the …

Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk

DP Strange, R Green, DN Siemann, M Gale Jr… - Scientific reports, 2018 - nature.com
Confirmed reports of Zika virus (ZIKV) in seminal fluid months after clearance of viremia
suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune …

Zika virus causes testis damage and leads to male infertility in mice

W Ma, S Li, S Ma, L Jia, F Zhang, Y Zhang, J Zhang… - Cell, 2016 - cell.com
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here,
we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in …

The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology

RN Almeida, HA Braz-de-Melo, IO Santos, R Corrêa… - Cells, 2020 - mdpi.com
Zika virus (ZIKV) has been reported by several groups as an important virus causing
pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular …