CLEC5A mediates Zika virus-induced testicular damage
HW Wang, HH Li, SC Wu, CK Tang, HY Yu… - Journal of Biomedical …, 2023 - Springer
Background Zika virus (ZIKV) infection is clinically known to induce testicular swelling,
termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain …
termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain …
CD8+ T cells promote ZIKV clearance and mitigate testicular damage in mice
Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters
and causes testicular damage in mouse models. The involvement of individual immune cells …
and causes testicular damage in mouse models. The involvement of individual immune cells …
Immunocompetent mouse models revealed that S100A4+ monocytes/macrophages facilitate long-term Zika virus infection in the testes
W Yang, C Zhang, LB Liu, ZZ Bian… - Emerging Microbes & …, 2024 - Taylor & Francis
During its global epidemic, Zika virus (ZIKV) attracted widespread attention due to its link
with various severe neurological symptoms and potential harm to male fertility. However, the …
with various severe neurological symptoms and potential harm to male fertility. However, the …
Single-cell RNA sequencing reveals the fragility of male spermatogenic cells to Zika virus-induced complement activation
W Yang, LB Liu, FL Liu, YH Wu, ZD Zhen… - Nature …, 2023 - nature.com
Zika virus (ZIKV) is a potential threat to male reproductive health but the mechanisms
underlying its influence on testes during ZIKV infection remain obscure. To address this …
underlying its influence on testes during ZIKV infection remain obscure. To address this …
Zika virus disrupts the barrier structure and Absorption/Secretion functions of the epididymis in mice
Z Sheng, N Gao, D Fan, N Wu, Y Zhang… - PLoS Neglected …, 2021 - journals.plos.org
Several studies have demonstrated that Zika virus (ZIKV) damages testis and leads to
infertility in mice; however, the infection in the epididymis, another important organ of male …
infertility in mice; however, the infection in the epididymis, another important organ of male …
IP-10 and CXCR3 signaling inhibit Zika virus replication in human prostate cells
JL Spencer Clinton, LL Tran, MB Vogt, DR Rowley… - Plos one, 2020 - journals.plos.org
Our previous studies have shown that Zika virus (ZIKV) replicates in human prostate cells,
suggesting that the prostate may serve as a long-term reservoir for virus transmission. Here …
suggesting that the prostate may serve as a long-term reservoir for virus transmission. Here …
Matrix metalloproteinase 9 facilitates Zika virus invasion of the testis by modulating the integrity of the blood-testis barrier
L Hui, Y Nie, S Li, M Guo, W Yang, R Huang… - PLoS …, 2020 - journals.plos.org
Zika virus (ZIKV) is a unique flavivirus with high tropism to the testes. ZIKV can persist in
human semen for months and can cause testicular damage in male mice. However, the …
human semen for months and can cause testicular damage in male mice. However, the …
Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk
Confirmed reports of Zika virus (ZIKV) in seminal fluid months after clearance of viremia
suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune …
suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune …
Zika virus causes testis damage and leads to male infertility in mice
W Ma, S Li, S Ma, L Jia, F Zhang, Y Zhang, J Zhang… - Cell, 2016 - cell.com
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here,
we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in …
we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in …
The cellular impact of the ZIKA virus on male reproductive tract immunology and physiology
RN Almeida, HA Braz-de-Melo, IO Santos, R Corrêa… - Cells, 2020 - mdpi.com
Zika virus (ZIKV) has been reported by several groups as an important virus causing
pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular …
pathological damage in the male reproductive tract. ZIKV can infect and persist in testicular …