Novel antibacterial compounds and their drug targets-successes and challenges

AA Kaczor, A Polski, K Sobótka-Polska… - Current medicinal …, 2017 - ingentaconnect.com
Infectious diseases are one of the most important and urgent health problems in the world.
According to the World Health Organization (WHO) statistics, infectious and parasitic …

[HTML][HTML] Current landscape of methods to evaluate antimicrobial activity of natural extracts

R Gonzalez-Pastor, SE Carrera-Pacheco… - Molecules, 2023 - mdpi.com
Natural extracts have been and continue to be used to treat a wide range of medical
conditions, from infectious diseases to cancer, based on their convenience and therapeutic …

Medicinal plants for the prevention and treatment of bacterial infections

GB Mahady - Current pharmaceutical design, 2005 - ingentaconnect.com
Infectious diseases are a significant cause of morbidity and mortality worldwide, accounting
for approximately 50% of all deaths in tropical countries and as much as 20% of deaths in …

[HTML][HTML] Antimicrobial potential of naturally occurring bioactive secondary metabolites

KS Allemailem - Journal of Pharmacy and Bioallied Sciences, 2021 - journals.lww.com
The use of traditional medicines of natural origin has been prevalent since ancient times
globally as the plants produce a great diversity in their secondary metabolites. The naturally …

A simple assay to screen antimicrobial compounds potentiating the activity of current antibiotics

J Iqbal, R Siddiqui, SU Kazmi… - BioMed Research …, 2013 - Wiley Online Library
Antibiotic resistance continues to pose a significant problem in the management of bacterial
infections, despite advances in antimicrobial chemotherapy and supportive care. Here, we …

Phytochemicals: a new arsenal in drug discovery

MH Ahmed, SI Karkush, SA Ali… - International Journal of …, 2024 - ijmsdh.org
In ancient times traditional herbs were used to treat different diseases such as stomach
discomfort, toothache, body pain and inflammation, diarrhea, malaria, typhoid, diabetes, and …

[HTML][HTML] Antibiotics: conventional therapy and natural compounds with antibacterial activity—a pharmaco-toxicological screening

DF Pancu, A Scurtu, IG Macasoi, D Marti, M Mioc… - Antibiotics, 2021 - mdpi.com
Antibiotics are considered as a cornerstone of modern medicine and their discovery offers
the resolution to the infectious diseases problem. However, the excessive use of antibiotics …

Antibacterial potential of diterpenoids

RCS Veneziani, SR Ambrósio, CHG Martins… - Studies in natural …, 2017 - Elsevier
Diterpenoids are a large and structurally diverse class of natural products derived from four
C5 isoprene units joined in a head-tail fashion. They are found mainly in plants and fungi …

[HTML][HTML] Efficacy and mechanism of traditional medicinal plants and bioactive compounds against clinically important pathogens

S Mickymaray - Antibiotics, 2019 - mdpi.com
Traditional medicinal plants have been cultivated to treat various human illnesses and avert
numerous infectious diseases. They display an extensive range of beneficial …

Pimarane‐type diterpenes obtained by biotransformation: antimicrobial properties against clinically isolated Gram‐positive multidrug‐resistant bacteria

TS Porto, MR Simão, LZ Carlos… - Phytotherapy …, 2013 - Wiley Online Library
The present study describes the antimicrobial activity of five pimarane‐type diterpenes
obtained by fungal biotransformation against several nosocomial multidrug‐resistant …