The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …

Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains
five immunoglobulin-like domains extracellularly and a catalytic domain divided into two …

The receptor tyrosine kinase c-Kit plays a critical role in hematopoiesis, and gain-of-function
mutations of the receptor are frequently seen in several malignancies, including acute …

The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …

The c-kit proto-oncogene encodes a receptor tyrosine kinase that is known to play a crucial
role in hematopoiesis, especially in mast cell growth and differentiation. Although a number …

Tyrosine phosphorylation has a key role in intracellular signaling. Inappropriate proliferation
and survival cues in tumor cells often occur as a consequence of unregulated tyrosine …

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several
highly malignant human cancers. Upon binding its ligand, stem cell factor (SCF), c-Kit forms …