Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A. X …

K Kumar, JPN Mishra, RP Singh - Chemico-biological interactions, 2020 - Elsevier
Usnic acid, a dibenzofuran derivative found in many lichen species, is reported to have
anticancer activity against human gastric cancer. We investigated the molecular alterations …

Changes in apoptosis-related gene expression profiles in cancer cell lines exposed to usnic acid lichen secondary metabolite

AB Dincsoy, DC Duman - Turkish Journal of Biology, 2017 - journals.tubitak.gov.tr
The presence of uninhibited side effects of cancer drugs often used in cancer treatment has
stimulated the search for alternative therapeutic approaches. Therefore, anticarcinogenic …

Usnic acid induces apoptosis via an ROS-dependent mitochondrial pathway in human breast cancer cells in vitro and in vivo

S Zuo, L Wang, Y Zhang, D Zhao, Q Li, D Shao… - RSC Advances, 2015 - pubs.rsc.org
Usnic acid (UA), an active dibenzofuran derivative mainly found in lichens, is considered an
antineoplastic agent based on its activity against tumor cells. However, the exact molecular …

[HTML][HTML] Usnic acid induces cycle arrest, apoptosis, and autophagy in gastric cancer cells in vitro and in vivo

X Geng, X Zhang, B Zhou, C Zhang, J Tu… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
Background Usnic acid (UA), a secondary metabolite, is mainly derived from certain lichen
species. Growing evidence suggests that UA has antitumor, anti-oxidative, anti …

Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo

X Wang, F Zhang, L Yang, Y Mei… - BioMed Research …, 2011 - Wiley Online Library
The aims of the study are to explore the effect of ursolic acid (UA) on the growth of gastric
cancer cell line BGC‐803 and hepatocellular cancer cell H22 xenograft and to understand …

Usnic acid: a non-genotoxic compound with anti-cancer properties

M Mayer, MA O'Neill, KE Murray… - Anti-cancer …, 2005 - journals.lww.com
The majority of human tumors bear inactive p53 or cellular factors that down-regulate the
expression and activity of the p53 network. Therefore, finding therapies that are effective in …

Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells

L Rawat, V Nayak - Toxicology Research, 2021 - academic.oup.com
Ursolic acid is a natural compound possessing several therapeutic properties including
anticancer potential. In present study, cytotoxic and antimetastatic properties of ursolic acid …

Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells

N Singh, D Nambiar, RK Kale, RP Singh - Nutrition and cancer, 2013 - Taylor & Francis
Usnic acid (UA) is a secondary metabolite abundantly found in lichens. Some studies have
shown the anticancer potential of UA; however, its efficacy and associated mechanisms are …

The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma

B Yurdacan, U Egeli, GG Eskiler… - Human & …, 2019 - journals.sagepub.com
Usnic acid (UA) is a multifunctional bioactive lichen secondary metabolite with potential anti-
cancer properties. Although the promising therapeutic effects of UA have been investigated …

[HTML][HTML] Ursolic acid inhibits the proliferation of gastric cancer cells by targeting miR-133a

F Xiang, C Pan, Q Kong, R Wu, J Jiang, Y Zhan… - Oncology …, 2015 - ncbi.nlm.nih.gov
Ursolic acid (UA), a potential chemotherapeutic agent, has the properties of inhibition of the
growth of many human cancer cell lines. Whether UA can inhibit the growth and metastasis …