Cholinergic receptors in cognitive disorders

EK Perry, RH Perry, CJ Smith, D Purohit… - Canadian Journal of …, 1986 - cambridge.org
Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have
been examined in the hippocampus obtained at autopsy from a variety of patients with …

Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases.

EK Perry, RH Perry, CJ Smith, DJ Dick… - Journal of Neurology …, 1987 - jnnp.bmj.com
The status of cholinergic receptors in dementia is related to the question of potential
cholinergic therapy. Whilst muscarinic receptor binding is generally reported to be normal or …

Brain nicotinic and muscarinic receptors in normal aging and dementia

A Nordberg, B Winblad - … and Parkinson's Disease: Strategies for Research …, 1986 - Springer
The cholinergic receptors are classically divided into two kinds, namely the nicotinic
acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these …

Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders.

PJ Whitehouse, KJ Kellar - Journal of neural transmission …, 1987 - europepmc.org
Alzheimer's disease (AD) and Parkinson's disease (PD) and to a lesser extent progressive
supranuclear palsy are characterized by dysfunction of the cholinergic basal forebrain …

The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer

E Giacobini, P DeSarno, B Clark, M McIlhany - Progress in brain research, 1989 - Elsevier
Publisher Summary The cholinergic system of the brain has been implicated in memory
function. Evidence for this role is anatomical, physiological and pharmacological. In all …

Cholinergic markers in Alzheimer disease and the autoregulation of acetylcholine release.

R Quirion - Journal of Psychiatry and Neuroscience, 1993 - ncbi.nlm.nih.gov
The status of various cholinergic markers was compared in Alzheimer's and Parkinson's
diseases. Rather unexpectedly, similar decrements were observed in choline …

Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders

CJ Smith, EK Perry, RH Perry, JM Candy… - Journal of …, 1988 - Wiley Online Library
Total muscarinic receptor levels, the levels of the subtypes exhibiting high and low affinity for
pirenzepine, and the high‐and low‐affinity agonist states of the receptor were investigated in …

Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex

KJ Kellar, PJ Whitehouse, AM Martino-Barrows… - Brain research, 1987 - Elsevier
The total population of muscarinic receptors and a subpopulation of muscarinic receptors
with high affinity for agonists were measured with [3 H] quinuclidinyl benzilate and [3 H] …

Muscarinic cholinoceptive neurons in the frontal cortex in Alzheimer's disease

H Schröder, E Giacobini, RG Struble, PGM Luiten… - Brain research …, 1991 - Elsevier
The cellular distribution of muscarinic acetylcholine receptor protein in the frontal cortex of
Alzheimer (AD) patients, age-matched and middle-aged controls was assessed …

Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer‐type dementia

S Shimohama, T Taniguchi, M Fujiwara… - Journal of …, 1986 - Wiley Online Library
Nicotinic and muscarinic cholinergic receptors were studied in autopsied brains from four
histologically normal controls and five histopathologically verified cases of Alzheimer‐type …