A randomized trial shows dose-frequency and genotype may determine the therapeutic efficacy of intranasal oxytocin

J Kou, Y Zhang, F Zhou, C Sindermann… - Psychological …, 2022 - cambridge.org
BackgroundThe neuropeptide oxytocin is proposed as a promising therapy for social
dysfunction by modulating amygdala-mediated social-emotional behavior. Although clinical …

[HTML][HTML] Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research

DS Quintana, A Lischke, S Grace, D Scheele… - Molecular …, 2021 - nature.com
Reports on the modulatory role of the neuropeptide oxytocin on social cognition and
behavior have steadily increased over the last two decades, stimulating considerable …

Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity

FB Spengler, J Schultz, D Scheele, M Essel, W Maier… - Biological …, 2017 - Elsevier
Background Current neuroimaging perspectives on a variety of mental disorders emphasize
dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the …

Oxytocin enhances resting-state connectivity between amygdala and medial frontal cortex

CS Sripada, KL Phan, I Labuschagne… - International Journal …, 2013 - academic.oup.com
The neuropeptide oxytocin (OXT) plays an important role in complex socio-affective
behaviours such as affiliation, attachment, stress and anxiety. Previous studies have focused …

Oxytocin's effect on resting-state functional connectivity varies by age and sex

NC Ebner, H Chen, E Porges, T Lin, H Fischer… - …, 2016 - Elsevier
The neuropeptide oxytocin plays a role in social cognition and affective processing. The
neural processes underlying these effects are not well understood. Modulation of …

Oxytocin-augmented psychotherapy: beware of context

R Hurlemann - Neuropsychopharmacology, 2017 - ncbi.nlm.nih.gov
The hypothalamic peptide oxytocin modulates a wide range of social and cognitive functions
in humans and nonhuman primates. As a result, much effort is currently being devoted to …

Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans

R Hurlemann, A Patin, OA Onur, MX Cohen… - Journal of …, 2010 - Soc Neuroscience
Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans
with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the …

Oxytocin differentially alters resting state functional connectivity between amygdala subregions and emotional control networks: Inverse correlation with depressive …

M Eckstein, S Markett, KM Kendrick, B Ditzen, F Liu… - Neuroimage, 2017 - Elsevier
The hypothalamic neuropeptide oxytocin (OT) has received increasing attention for its role in
modulating social-emotional processes across species. Previous studies on using intranasal …

Oral oxytocin facilitates responses to emotional faces in reward and emotional-processing networks in females

C Lan, Y Chen, Y Zhang, J Kou, L Huang, T Xu… - …, 2023 - karger.com
Introduction: Oxytocin (OXT) is proposed as a potential therapeutic peptide for social
dysfunction due to its modulatory actions on socioemotional regulation in humans. While the …

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men

J Lieberz, D Scheele, FB Spengler… - …, 2020 - nature.com
Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala
responses to fear-related stimuli in men, while exerting inverse effects in women. However …