This viewpoint considers four cutaneous unmet clinical needs of patients with systemic
sclerosis (SSc), namely the rapidly progressive skin thickening (scleroderma) which occurs …

Systemic sclerosis (SSc, scleroderma) is a multifaceted rare connective tissue disease
whose pathogenesis is dominated by immune dysregulation, small vessel vasculopathy …

Virtually all patients with systemic sclerosis (SSc) experience cutaneous sclerosis and
Raynaud's phenomenon (RP), although substantial variability in the presentation and …

Microvascular damage and dysfunction represent the earliest morphological and functional
markers of systemic sclerosis (SSc), a progressive connective tissue disease characterized …

Systemic sclerosis (also called scleroderma, SSc) is a chronic autoimmune disorder
characterized by excessive collagen deposition leading to skin fibrosis and various internal …

Despite progress in treating internal organ involvement in systemic sclerosis
(scleroderma)(SSc), such as pulmonary disease, effective treatments for the hallmark of the …

Introduction: The cutaneous vascular manifestations of systemic sclerosis (SSc) comprise
Raynaud's phenomenon, cutaneous ulceration, telangiectasia formation and critical digital …

Skin ulceration is an important cause of morbidity in systemic sclerosis and can occur at
anytime during disease progression. Incident disease cohorts are important for …

Systemic sclerosis is an uncommon autoimmune connective tissue disease with multiorgan
system involvement and significant associated morbidity and mortality. Cutaneous signs and …

Recent years have witnessed remarkable progress in our understanding of the
pathogenesis of systemic sclerosis (SSc, scleroderma), which in turn has fostered realization …