We developed a sensitive real-time polymerase chain reaction (QPCR) assay that allows us
to track early lodging/homing events in vivo. We used this technology to develop a …

Metastatic disease is a main cause of mortality in prostate cancer and remains to be
incurable despite emerging new treatment agents. Development of novel treatment agents …

The complex dynamics of the tumor microenvironment and prostate cancer heterogeneity
have confounded efforts to establish suitable preclinical mouse models to represent human …

Purpose: Transgenic mouse models are proving to be invaluable in our effort to understand
the molecular basis of metastatic prostate cancer (CaP). We review and discuss how current …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

Prostate cancer is the most common malignancy in American males and is second only to
lung cancer as a cause of death in the United States. Clinically, radical prostatectomy offers …

PURPOSE: The metastasis of prostate cancer to bone is the most significant cause of
morbidity and mortality in this disease. An estimated 28,900 men die annually secondary to …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Tumor cell dissemination to distant organs accounts for the majority of cancer related
deaths. Analysis of the stepwise process of metastasis formation and progression might …

Although intensely studied, the molecular and biochemical determinants of prostate cancer
development and progression remain ill‐defined. Moreover, current markers and …