Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

M Raices, MA D'angelo - Nature reviews Molecular cell biology, 2012 - nature.com
Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

The nuclear pore complex–structure and function at a glance

G Kabachinski, TU Schwartz - Journal of cell science, 2015 - journals.biologists.com
Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of
several human diseases. NPCs provide access to the nucleus and regulate the transport of …

The role of nuclear pores in gene regulation, development and disease

M Capelson, MW Hetzer - EMBO reports, 2009 - embopress.org
Nuclear‐pore complexes (NPCs) are large protein channels that span the nuclear envelope
(NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of …

The nuclear pore complex: understanding its function through structural insight

M Beck, E Hurt - Nature reviews Molecular cell biology, 2017 - nature.com
Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …

Nucleoporin domain topology is linked to the transport status of the nuclear pore complex

SM Paulillo, EM Phillips, J Köser, U Sauder… - Journal of molecular …, 2005 - Elsevier
Nuclear pore complexes (NPCs) facilitate macromolecular exchange between the nucleus
and cytoplasm of eukaryotic cells. The vertebrate NPC is composed of∼ 30 different …

Functional architecture of the nuclear pore complex

E Grossman, O Medalia… - Annual review of …, 2012 - annualreviews.org
The nuclear pore complex (NPC) is the sole gateway between the nucleus and the
cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous …

Nuclear pore proteins and the control of genome functions

A Ibarra, MW Hetzer - Genes & development, 2015 - genesdev.cshlp.org
Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …

Biology and biophysics of the nuclear pore complex and its components

RYH Lim, KS Ullman, B Fahrenkrog - … review of cell and molecular biology, 2008 - Elsevier
Nucleocytoplasmic exchange of proteins and ribonucleoprotein particles occurs via nuclear
pore complexes (NPCs) that reside in the double membrane of the nuclear envelope (NE) …

Structural analysis of the nuclear pore complex by integrated approaches

N Elad, T Maimon, D Frenkiel-Krispin, RYH Lim… - Current opinion in …, 2009 - Elsevier
In eukaryotic cells, the nucleus is surrounded by a double membrane system, the nuclear
envelope (NE), in which the outer membrane is continuous with the endoplasmic reticulum …

Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex

IC Berke, T Boehmer, G Blobel… - The Journal of cell biology, 2004 - rupress.org
Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) whose
complex architecture is generated from a set of only∼ 30 proteins, termed nucleoporins …