A pilot scale whole cell process was developed for the enantioselective 1, 2‐reduction of
prochiral α, β‐unsaturated ketone to (R) allylic alcohol using Candida chilensis. Initial …

The increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols
results from the outstanding characteristics of biocatalysts in reaction, economic, and …

Enzymes are able to perform reactions under mild conditions, eg, pH and temperature, with
remarkable chemo-, regio-, and stereoselectivity. Due to this feature the number of …

Selected examples of asymmetric bioreductions of pharmaceutically relevant prochiral
ketones are reviewed. These data show that microbial screens lead to the identification of …

The screening of 129 fungal and yeasts strains yielded Candida magnoliae MY 1785 as a
suitable biocatalyst for the asymmetric bioreduction of cyclohexylphenyl ketone to its …

Background Chiral alcohols are widely used in the synthesis of chiral pharmaceuticals,
flavors and functional materials and appropriate whole-cell biocatalysts offer a highly …

Candida utilis can grow efficiently in a simple synthetic medium at low pH. The electron
donor for yeast-mediated enantioselective bioreduction of acetophenone was ethanol …

The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the
reduction of prochiral ketones have been compared with the ones previously attained in our …

Background Whole cell-catalyzed biotransformation is a clear process option for the
production of chiral alcohols via enantioselective reduction of precursor ketones. A wide …

Whole-cell biocatalysts offer a highly enantioselective, minimally polluting route to optically
active alcohols. Currently, most of the whole-cell catalytic performance involves resting cells …