Stimulation of the secondary somatosensory cortex (S2) has attenuated pain in humans and
inflammatory nociception in animals. Here we studied S2 stimulation-induced …

Electric stimulation of the primary motor cortex (M1) has been effective in suppressing pain-
related responses in neuropathic as well as healthy control animals. We studied whether the …

Background The descending antinociceptive system (DAS) is thought to play crucial roles in
the antinociceptive effect of spinal cord stimulation (SCS), especially through its serotonergic …

The aim of the present study was to examine the role of the spinal serotonergic system in the
pain relieving effect of spinal cord stimulation (SCS) using a rat model of mononeuropathy …

The neurobiological mechanisms underlying the suppression of neuropathic pain by spinal
cord stimulation (SCS) are still incompletely known. The present study aims at exploring …

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …

Pain resulting from peripheral nerve injury, characterised by ongoing pain, hyperalgesia and
allodynia arises from peripheral and central processes. Here, we studied the potential role of …

The rostroventromedial medulla (RVM) is an important source of descending modulatory
systems that both inhibit and facilitate pain at the level of the spinal cord. Noxious stimuli can …

Clinical and immunohistochemical evidence suggests the possible significance of electrical
stimulation of the secondary somatosensory cortex (S-II) as an analgesic therapy. The aim of …

We have read with interest the article by Li et al.(1) entitled “Spinal Cord Stimulation With
'Conventional Clinical'and Higher Frequencies on Activity and Responses of Spinal …