Modified benzoxazole-based VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, and anti-proliferative evaluation
This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …
promising derivative of our previous work concerned with the development of VEGFR-2 …
Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors …
AM Saleh, HA Mahdy, MA El-Zahabi, ABM Mehany… - RSC …, 2023 - pubs.rsc.org
A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …
moieties with different linkers (spacers) were designed and synthesized as possible …
Novel 4-(piperazin-1-yl) quinolin-2 (1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition
Abstract A new series of 2-(4-(2-oxo-1, 2-dihydroquinolin-4-yl) piperazin-1-yl)-N-(4-
phenylthiazol-2-yl) acetamide derivatives were synthesized and evaluated for anticancer …
phenylthiazol-2-yl) acetamide derivatives were synthesized and evaluated for anticancer …
Identification of new [1, 2, 4] triazolo [4, 3-a] quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies
Tumor angiogenesis is mainly regulated by VEGFR-2. In this study, a new series of [1, 2, 4]
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
triazolo [4, 3-a] quinoxaline based-derivatives has been designed and synthesized to …
Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers
Herein, a new wave of bis ([1, 2, 4] triazolo)[4, 3-a: 3', 4'-c] quinoxaline derivatives have been
successfully designed and synthesised. The synthesised derivatives were biologically …
successfully designed and synthesised. The synthesised derivatives were biologically …
Design, synthesis, and antiproliferative properties of new 1, 2, 3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors
A new series of substituted aryl carboximidamide VIa-o was designed and synthesised. IR, 1
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
H NMR, 13 C NMR as well as elemental microanalysis were used to confirm the structures of …
Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies
This study aimed to design anticancer theobromine derivatives inhibiting VEGFR-2. The new
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
compounds were tested in vitro to evaluate their effectiveness against MCF-7 and HepG2 …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile
Aim: Design and synthesis of thienopyrimidine derivatives as dual EGFR and VEGFR-2
inhibitors. Material and methods: A series of novel 6, 7, 8, 9-tetrahydro-5 H-cyclohepta [4, 5] …
inhibitors. Material and methods: A series of novel 6, 7, 8, 9-tetrahydro-5 H-cyclohepta [4, 5] …
Discovery of novel potent VEGFR-2 inhibitors exerting significant antiproliferative activity against cancer cell lines
Computational and experimental studies were applied to the discovery of a series of novel
vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors. Eight compounds …
vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors. Eight compounds …