Apolipoprotein (a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

A Helgadottir, S Gretarsdottir, G Thorleifsson… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study is investigate the effects of variants in the
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …

A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk

T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …

Genetic variants in the apolipoprotein (a) gene and coronary heart disease

Y Li, MM Luke, D Shiffman, JJ Devlin - Circulation: Cardiovascular …, 2011 - Am Heart Assoc
Two independent single-nucleotide polymorphisms (SNPs) in the gene encoding
apolipoprotein (a)(LPA) have been shown to be associated with coronary heart disease …

Lipoprotein (a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study

JC Hopewell, R Clarke, S Parish… - Circulation …, 2011 - Am Heart Assoc
Background—Genetic studies have identified 2 single-nucleotide polymorphisms (SNPs) at
the LPA locus (rs3798220 and rs10455872) that are strongly and independently related to …

A polymorphism in the protease-like domain of apolipoprotein (a) is associated with severe coronary artery disease

MM Luke, JP Kane, DM Liu, CM Rowland… - … , and vascular biology, 2007 - Am Heart Assoc
Objectives—The purpose of this study was to identify genetic variants associated with
severe coronary artery disease (CAD). Methods and Results—We used 3 case-control …

Polymorphism in the apolipoprotein (a) gene, plasma lipoprotein (a), cardiovascular disease, and low-dose aspirin therapy

DI Chasman, D Shiffman, RYL Zee, JZ Louie, MM Luke… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: A minor allele variant (rs3798220) of apolipoprotein (a) has been reported to
be associated with elevated plasma lipoprotein (a)[Lp (a)] and increased cardiovascular risk …

Phenotypic characterization of genetically lowered human lipoprotein (a) levels

CA Emdin, AV Khera, P Natarajan, D Klarin… - Journal of the American …, 2016 - jacc.org
Background: Genomic analyses have suggested that the LPA gene and its associated
plasma biomarker, lipoprotein (a)(Lp [a]), represent a causal risk factor for coronary heart …

Lipoprotein (a) and long-term cardiovascular risk in a multi-ethnic pooled prospective cohort

ND Wong, W Fan, X Hu, C Ballantyne… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp [a]) is a causal genetic risk factor for atherosclerotic
cardiovascular disease (ASCVD). There are limited long-term follow-up data from large US …

Apolipoprotein (a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants

S Erqou, A Thompson, E Di Angelantonio… - Journal of the American …, 2010 - jacc.org
Objectives: The purpose of this study was to assess the association of apolipoprotein
(a)(apo [a]) isoforms with cardiovascular disease risk. Background: Although circulating …

Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk

B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …