Xenotransplantation: an update on recent progress and future perspectives
P Bucher, P Morel, LH Bühler - Transplant international, 2005 - Wiley Online Library
Currently, the number of patients awaiting transplantation is continuously increasing, and
shortage of available deceased organ donors is the major limitation for organ and cell …
shortage of available deceased organ donors is the major limitation for organ and cell …
Assembling multiple xenoprotective transgenes in pigs
K Fischer, A Kind, A Schnieke - Xenotransplantation, 2018 - Wiley Online Library
This review gives a brief overview of the genetic modifications necessary for grafted porcine
tissues and organs to overcome rejection in human recipients. It then focuses on the …
tissues and organs to overcome rejection in human recipients. It then focuses on the …
Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival
AB Adams, SC Kim, GR Martens, JM Ladowski… - Annals of …, 2018 - journals.lww.com
Objective: Xenotransplantation using pig organs could end the donor organ shortage for
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …
Potential use of genetically modified pigs as organ donors for transplantation into humans
JS Logan, A Sharma - Clinical and experimental …, 1999 - Wiley Online Library
Transplantation is currently viewed as a successful treatment for end‐stage organ failure. Its
more widespread use is severely limited by a shortage of human organ donors. This has …
more widespread use is severely limited by a shortage of human organ donors. This has …
International standards and guidelines for xenotransplantation
WJ Hawthorne, PJ Cowan, L Buhler, E Wolf - Nature Biotechnology, 2021 - nature.com
2. US Food & Drug Administration. Xenotransplantation guidances. https://www. fda.
gov/vaccines-blood-biologics/biologics-guidances/xenotransplantation-guidances (2016). 3 …
gov/vaccines-blood-biologics/biologics-guidances/xenotransplantation-guidances (2016). 3 …
Prospects for xenotransplantation
JS Logan - Current Opinion in Immunology, 2000 - Elsevier
Pig-to-primate organ survival has been extended from a few minutes to weeks and
occasionally months, following the development of transgenic pigs that express human …
occasionally months, following the development of transgenic pigs that express human …
Progress in multiple genetically modified minipigs for xenotransplantation in China
D Pan, T Liu, T Lei, H Zhu, Y Wang… - Xenotransplantation, 2019 - Wiley Online Library
Pig‐to‐human organ transplantation provides an alternative for critical shortage of human
organs worldwide. Genetically modified pigs are promising donors for xenotransplantation …
organs worldwide. Genetically modified pigs are promising donors for xenotransplantation …
Advances in organ transplant from pigs
J Denner - Science, 2017 - science.org
Xenotransplantation, where tissue from one species is transplanted into a different species,
is currently under development to help alleviate the increasing shortage of human tissues …
is currently under development to help alleviate the increasing shortage of human tissues …
[HTML][HTML] The immense potential of xenotransplantation in surgery
DKC Cooper, D Ayares - International Journal of Surgery, 2011 - Elsevier
There is a limited availability of deceased human organs and cells for the purposes of
clinical transplantation. Genetically-engineered pigs may provide an alternative source …
clinical transplantation. Genetically-engineered pigs may provide an alternative source …
Xenotransplantation: current challenges and emerging solutions
To address the ongoing shortage of organs available for replacement, xenotransplantation
of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing …
of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing …