Currently, the number of patients awaiting transplantation is continuously increasing, and
shortage of available deceased organ donors is the major limitation for organ and cell …

This review gives a brief overview of the genetic modifications necessary for grafted porcine
tissues and organs to overcome rejection in human recipients. It then focuses on the …

Objective: Xenotransplantation using pig organs could end the donor organ shortage for
transplantation, but humans have xenoreactive antibodies that cause early graft rejection …

Transplantation is currently viewed as a successful treatment for end‐stage organ failure. Its
more widespread use is severely limited by a shortage of human organ donors. This has …

2. US Food & Drug Administration. Xenotransplantation guidances. https://www. fda.
gov/vaccines-blood-biologics/biologics-guidances/xenotransplantation-guidances (2016). 3 …

Pig-to-primate organ survival has been extended from a few minutes to weeks and
occasionally months, following the development of transgenic pigs that express human …

Pig‐to‐human organ transplantation provides an alternative for critical shortage of human
organs worldwide. Genetically modified pigs are promising donors for xenotransplantation …

Xenotransplantation, where tissue from one species is transplanted into a different species,
is currently under development to help alleviate the increasing shortage of human tissues …

There is a limited availability of deceased human organs and cells for the purposes of
clinical transplantation. Genetically-engineered pigs may provide an alternative source …

To address the ongoing shortage of organs available for replacement, xenotransplantation
of hearts, corneas, skin, and kidneys has been attempted. However, a major obstacle facing …