Modern antiretroviral therapy (ART) has saved millions of years of life [1], but it cannot
eradicate latently infected cells [2, 3]. The replication-competent provirus that remains during …

Achieving a cure for HIV remains a priority in HIV research. Two cases of 'sterilizing
cure'have been observed—in Timothy Ray Brown and the “London” patient; both patients …

The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …

Human immunodeficiency virus (HIV) has exacted a terrible toll on individuals and
populations around the world. By 2017 this virus had already resulted in the death of∼ 35 …

The case of the “Berlin Patient” is well-known. In 2007, an HIV-infected adult with leukemia
underwent allogeneic hematopoietic stem cell transplant and was cured of his cancer …

Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related
mortality and morbidity; however, HIV can still not be cured. Achieving either a functional …

The reservoir of human immunodeficiency virus type 1 (HIV-1), a long-lived pool of latently
infected cells harboring replication-competent viruses, is the major obstacle to curing …

Achieving cure of HIV infection requires eliminating all replication-competent virus from the
reservoir of latently infected cells or completely inhibiting infected cells from emerging from …

Highly active antiretroviral therapy dramatically improves survival in HIV-infected patients.
However, persistence of HIV in reservoirs has necessitated lifelong treatment that can be …

Curing HIV infection moved from the aspirational to the theoretically plausible with the
apparent elimination of latent HIV from Timothy Ray Brown, also known as the Berlin Patient …