Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

Previous studies have shown that adolescent exposure to cocaine increases drug use in
adulthood, albeit incubation of cocaine seeking was found to be attenuated in rats trained to …

Adolescence marks a particularly vulnerable period to developing substance use disorders,
and people who start using drugs in adolescence are more likely to relapse. A limited …

Human and animal laboratory studies show that adolescents and adults respond differently
to drugs and that drug administration during adolescence leads to different behavioral …

Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …

Rationale Adult rats typically exhibit more robust behavioral sensitization than do
preweanling rats. A possible explanation for this age-dependent difference is that …

Human and animal laboratory studies show that females and males respond differently to
drugs and that drug administration during adolescence leads to different behavioral effects …

Rationale Adolescence is a critical period for drug addiction. Acute stimulant exposure elicits
different behavioral responses in adolescent and adult rodents. The same biological …

It is thought that rewarding experiences with drugs create strong contextual associations and
encourage repeated intake. In turn, repeated exposures to drugs of abuse make lasting …

As addiction is increasingly formulated as a developmental disorder, identifying how early
developmental exposures influence later responses to drugs of abuse is important to our …