The potential for addiction is thought to be greatest when drugs of abuse reach the brain
rapidly, because this produces intense subjective pleasurable effects. However, the ability of …

Rationale Epidemiological evidence of early adolescent tobacco use, prior to that of
marijuana and other illicit drugs, has led to the hypothesis that nicotine is a “gateway” drug …

Adolescent rats take cocaine more readily than adults, are more sensitive to lower doses of
the drug and work harder for it. It remains unknown if adolescent‐onset of cocaine use has …

Rationale Previous studies have shown that environmental context can powerfully modulate
the induction of psychomotor sensitization to cocaine in the rat. Rats that receive repeated …

This study was done to determine whether social and environmental factors alter cocaine
reward and proteins implicated in mediating drug reward in rats during early adolescence …

Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity
including behavioral sensitization. Although a single exposure to many addicting …

The study tested the possibility of a positive relationship between the dose of cocaine and
the size of the placebo effect generated after contextual sensitisation to the behavioural …

Rationale and objective We sought to examine the impact of differing cocaine administration
schedules and dosing on the magnitude of cocaine conditioned place preference (CPP) …

Heading Abstract Rationale. At least 40,000 infants born each year in the US are estimated
to have been exposed to crack cocaine and, therefore, may be at risk for increased …

Previous studies have demonstrated that rats showing a strong locomotor response to a
novel environment have a greater locomotor response to psychostimulant drugs and more …