In recent years, growing evidence has suggested a prominent role of oxidative stress in the
pathophysiology of several early-and adult-onset muscle disorders, although effective …

Oxidative stress is a loss of balance between the production of reactive oxygen species
during cellular metabolism and the mechanisms that clear these species to maintain cellular …

Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an
X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by …

Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …

Imbalances in redox homeostasis can result in oxidative stress, which is implicated in
various pathological conditions including the fatal neuromuscular disease Duchenne …

Significance: Skeletal muscles have a robust regenerative capacity in response to acute and
chronic injuries. Muscle repair and redox homeostasis are intimately linked; increased …

Age-associated decline in antioxidant potential and accumulation of reactive
oxygen/nitrogen species are primary causes for multiple health problems, including …

Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we
discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) …

Skeletal muscles comprise the largest organ system in the body and play an essential role in
body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important …

Because of their contractile activity and their high oxygen consumption and metabolic rate,
skeletal muscles continually produce moderate levels of reactive oxygen and nitrogen …