The Epithelial-to-Mesenchymal Transition (EMT) is a cell-biological process that operates
during embryonic development, wound-healing, and carcinoma progression. During this …

Although the advent of new immunotherapy approaches has improved survival for many
patients with advanced malignancies, the high degree of nonresponders, especially in …

The tremendous success of immune checkpoint blockades has revolutionized cancer
management. Our increased understanding of the cell types that compose the tumor …

Cellular and phenotypic plasticity is a key feature of development and normal function of
cells withinmostmulticellularorganisms. Theabilitytorespondtovariousintrinsicandext …

Cancer immunotherapy, including immune checkpoint blockade and CAR-T cell therapy,
has introduced revolutionary approaches to treating patients with cancer. The success and …

Simple Summary Epithelial-to-mesenchymal transition (EMT) is a complex program by
which epithelial cells lose epithelial characteristics whilst acquiring mesenchymal features …

Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

The epithelial-to-mesenchymal transition (EMT) is commonly considered as a main driving
force of the metastatic cascade. An impressive series of experiments and observations …

Novel immunotherapy approaches have provided durable remission in a significant number
of cancer patients with cancers previously considered rapidly lethal. Nonetheless, the high …

The development and clinical application of immune modulation represent one of the most
extraordinary achievements in the treatment of cancer. Monoclonal antibodies against …