Large interindividual differences occur in human nicotine disposition, and it has been
proposed that genetic polymorphisms in nicotine metabolism may be a major determinant of …

The molecular genetics of nicotine metabolism involves multiple polymorphic catalytic
enzymes. Variation in metabolic pathways results in nicotine disposition kinetics that differ …

Nicotine has roles in the addiction to smoking, replacement therapy for smoking cessation,
as a potential medication for several diseases such as Parkinson's disease, Alzheimer's …

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Nicotine is the psychoactive substance responsible for tobacco dependence; smokers adjust
their cigarette consumption to maintain brain nicotine levels. In humans, 70 to 80% of …

Background Studies on cytochrome P450 (CYP) 2A6 suggest that genotype affects the rate
of nicotine metabolism and, consequently, cigarette consumption. However, known alleles of …

Nicotine (NIC), the major constituent of tobacco, is responsible for the compulsive use of
tobacco. Advances in understanding of the pharmacokinetics and metabolism of NIC have …

Nicotine is the primary compound present in tobacco that is responsible for establishing and
maintaining tobacco dependence; dependent smokers adjust their smoking behavior to …

Background Flavin-containing monooxygenases (FMO) catalyze the metabolism of
nucleophilic heteroatom-containing drugs and xenobiotics, including nicotine. Rare …

Nicotine is the primary addictive agent in tobacco, and P450 2A6 (gene name: CYP2A6) is
the primary catalyst of nicotine metabolism. It was proposed more than 20 years ago that …