Mitochondrial dysregulation and associated excessive reactive oxygen species (mtROS)
production is a key source of oxidative stress in aging arteries that reduces baseline function …

Key points The results of the present study establish the temporal pattern of age‐related
vascular dysfunction across the adult lifespan in sedentary mice consuming a non‐Western …

Key points The development of age‐related arterial endothelial dysfunction, a key
antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced …

Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive
dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen …

Aging leads to large vessel arterial stiffening and endothelial dysfunction, which are
important determinants of cardiovascular risk. The aim of present work was to assess the …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial
respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial …

Aim This study sought to determine the role of free radicals derived from mitochondria in the
vasculature in the recognized age‐related endothelial dysfunction of human skeletal muscle …

Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO)
bioavailability. Life‐long caloric restriction (CR) reduces oxidative stress, but its impact on …