Aging is a major factor in the decline of limb blood flow with ischemia. However, the
underlying mechanism remains unclear. We investigated the role of mitochondrial reactive …

Key points Reducing excessive oxidative stress, through chronic exercise or antioxidants,
can decrease the negative effects induced by excessive amounts of oxidative stress …

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries,
which causes claudication. This may be in part due to vascular mitochondrial dysfunction …

Excessive reactive oxygen species production by mitochondria (mtROS) is a key contributor
to age-related vascular endothelial dysfunction. We recently showed in a crossover design …

Exercise training is recognized to improve cardiac and skeletal muscle mitochondrial
respiratory capacity; however, the impact of chronic exercise on vascular mitochondrial …

Epidemiological studies demonstrate that in addition to the increased prevalence of
hypertension in old patients, the deleterious cerebrovascular effects of hypertension …

Age is the major risk factor for cardiovascular diseases (CVD) and this is attributable in part
to stiffening of large elastic arteries and development of vascular endothelial dysfunction (eg …

To determine if short‐term calorie restriction reverses vascular endothelial dysfunction in old
mice, old (O, n= 30) and young (Y, n= 10) male B6D2F1 mice were fed ad libitum (AL) or …

Aging is the basis for several unfavorable conditions, including cardiovascular diseases
(CVDs). In this sense, regular physical activity (regular PA) has been proven to delay cellular …

Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …