Oxidative stress and inflammation are increased with advancing age. Evidence suggests
that oxidative stress and inflammation both lead to impaired vascular function. There is also …

Key points Vascular oxidative stress increases with advancing age. We hypothesized that
resistance vessels develop resilience to oxidative stress to protect functional integrity and …

Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and
mortality in older people. Mitochondria play an important role in vascular aging. In …

Mitochondrial biogenesis is involved in the control of cell metabolism, signal transduction,
and regulation of mitochondrial reactive oxygen species (ROS) production. Despite the …

Vascular aging is characterized by increased oxidative stress, impaired nitric oxide (NO)
bioavailability and enhanced apoptotic cell death. The oxidative stress hypothesis of aging …

Background Senescence is a major factor that increases oxidative stress in mitochondria,
which contributes toward the pathogenesis of heart disease. However, the effect of …

Aging is associated with increased free radical generation in the skeletal muscle that can
cause oxidative modification of protein, lipid, and DNA. Physical activity has many well …

Ageing is associated with several physiological declines to both the cardiovascular (eg
reduced aerobic capacity) and musculoskeletal system (muscle function and mass). Ageing …

Key points Vascular brain lesions and atherosclerosis are two similar conditions that are
characterized by increased inflammation and oxidative stress. Non‐invasive imaging in a …

Vascular aging contributes to adverse changes in organ function and is a significant
indicator of major cardiac events. Endothelial cells (ECs) participate in aging-provoked …