Epidemiological studies demonstrated that even in the absence of other risk factors (eg,
diabetes, hypertension, hypercholesterolemia), vascular aging significantly increases …

Vascular aging contributes to adverse changes in organ function and is a significant
indicator of major cardiac events. Endothelial cells (ECs) participate in aging-provoked …

Background: Aging and low physical activity are associated with the development of
diseases (hypertension, type 2 diabetes, dyslipidemia, obesity) marked by chronic low …

Cognitive performances are tightly associated with the maximal aerobic exercise capacity,
both of which decline with age. The benefits on mental health of regular exercise, which …

Vascular aging is characterized by decreased nitric oxide (NO) bioavailability, oxidative
stress, and enhanced apoptotic cell death. We hypothesized that interspecies comparative …

Nutritional supplements, calorie restriction, and life style change are the most effective
preventive strategies to improve mitochondrial function and reduce mitochondrial oxidative …

Chronic exercise training is known to protect the vasculature; however, the underlying
mechanisms remain obscure. The present study hypothesized that exercise may improve …

Aging-induced functional and phenotypic alterations of the vasculature (eg, endothelial
dysfunction, oxidative stress) have a central role in morbidity and mortality of older adults. It …

Impaired mitochondrial function has been implicated in the pathogenesis of age-associated
metabolic diseases through regulation of cellular redox balance. Exercise training is known …

Vascular ageing can be envisioned as the consequence of the accumulation of reactive
oxygen species (ROS) associated with generalized endothelial dysfunction. Oxidative stress …