Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth

P Laakkonen, M Waltari, T Holopainen, T Takahashi… - Cancer research, 2007 - AACR
Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is
essential for the development of the lymphatic vasculature. Experimental tumors that …

Inhibition of solid tumor growth by gene transfer of VEGF receptor‐1 mutants

R Heidenreich, M Machein, A Nicolaus… - … journal of cancer, 2004 - Wiley Online Library
Vascular endothelial growth factor (VEGF) and the high‐affinity VEGF receptor Flk‐1/KDR
(VEGFR‐2) are key regulators of tumor angiogenesis. Strategies to block VEGF/VEGFR‐2 …

Differential behavior of VEGF receptor expression and response to TNP-470 in two immortalized human endothelial cell lines.

M Seki, M Toi, K Kobayashi… - International …, 2000 - spandidos-publications.com
Angiogenesis consists of endothelial cell proliferation, migration and tube formation. It is
useful to investigate endothelial cell behavior using immortalized endothelial cell lines. We …

Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and …

J Drevs, I Hofmann, H Hugenschmidt, C Wittig… - Cancer Research, 2000 - AACR
Antiangiogenic therapy is a promising new strategy to inhibit tumor growth and formation of
metastases. Vascular endothelial growth factor (VEGF) and its receptors, VEGF-receptor 1 …

A fusion fragment from Flt-1 and KDR, acted as VEGF decoy receptor and exhibited anti-tumor function

ZL Li, XJ Yao, WF Liu, GJ Chen - Biotechnology letters, 2010 - Springer
Angiogenesis is important in tumor development. Vascular endothelial growth factor (VEGF)
is involved in this process. In this report, we constructed a recombinant protein (called FK) by …

The role of vascular endothelial growth factor (VEGF) in tumor angiogenesis and early clinical development of VEGFReceptor kinase inhibitors

HMW Verheul, HM Pinedo - Clinical Breast Cancer, 2000 - Elsevier
Angiogenesis, or the formation of new blood vessels from preexisting vasculature, plays a
major role in tumor growth and metastasis formation. Therefore, inhibiting tumor …

VEGF–VEGF receptor complexes as markers of tumor vascular endothelium

RA Brekken, PE Thorpe - Journal of Controlled Release, 2001 - Elsevier
Vascular endothelial growth factor (VEGF) is a primary stimulant of the vascularization of
solid tumors and has therefore been the focus of intense research aimed at blocking its …

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

CJ Robinson, SE Stringer - Journal of cell science, 2001 - journals.biologists.com
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …

Vascular endothelial growth factor as a marker of tumor endothelium

RA Brekken, X Huang, SW King, PE Thorpe - Cancer research, 1998 - AACR
Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is a primary
stimulant of the vascularization of solid tumors. VEGF production is induced by oncogenic …

Tumor-derived vascular endothelial growth factor (VEGF)-a facilitates tumor metastasis through the VEGF-VEGFR1 signaling pathway

W Liu, J Xu, M Wang, Q Wang… - … journal of oncology, 2011 - spandidos-publications.com
Vascular endothelial growth factor (VEGF) and its receptors are involved in carcinogenesis,
invasion and tumor angiogenesis, but the underlying mechanism by which VEGF promotes …