Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

STUDY QUESTION Does in vivo aging of mouse oocytes affect mitochondrial function?
SUMMARY ANSWER Mitochondrial function was impaired in post-ovulatory in vivo-aged …

Purpose To establish the phenotype of reproductive aging in our mouse model. To test the
hypotheses that reproductive aging is associated with a decrease in mitochondrial …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Mitochondrial dysfunction may be acquired or inherited by oocytes without detectable
morphological abnormalities. This pathology may account for some examples of …

Germinal vesicle transplantation (GVT) has been proposed as a possible treatment to
correct age-related oocyte aneuploidy caused by dysfunctional ooplasm. How healthy …

Background In human oocytes, as in other mammalian ova, there is a significant variation in
the pregnancy potential, with approximately 20% of oocyte-sperm meetings resulting in …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

In recent years, postponement of marriage and childbearing in women of reproductive age
has led to an increase in the incidence of age-related infertility. The reproductive aging …