Background Methods The GRN mutations, especially of the loss of function type, are
causative of frontotemporal dementia (FTD). However, several GRN variants can be found in …

Background: During the twentieth century, frontotemporal dementia (FTD) was often
misdiagnosed, confused with Alzheimer's disease or psychiatric disorders, jeopardizing care …

Mutations in the progranulin gene (GRN) are responsible for familial FTLD with ubiquitin
pathology (FTLD-U). However, there are controversial data regarding the contribution of …

Background: Progranulin protein (PGRN) is a cysteine-rich growth factor encoded by the
progranulin gene (GRN). PGRN mutations were identified in patients with frontotemporal …

Backgrounds Alzheimer's disease (AD) and fronto-temporal dementia (FTD) are the two
most common neurodegenerative diseases leading to early onset dementia (< 65 years) …

Progranulin (GRN) gene mutations have been genetically associated with frontotemporal
dementia (FTD) and are present in about 23% of patients with familial FTD. However, the …

Frontotemporal lobar degeneration (FTLD) refers to a clinically, pathologically, and
genetically heterogeneous group of dementias that arises from the degeneration of the …

Background: Progranulin protein (GRN) is a growth factor, encoded by the GRN (Granulin
precursor) gene, involved in several functions including inflammation, wound repair, signal …

Mutations in the progranulin gene (GRN) were recently identified as an important cause of
familial frontotemporal dementia (FTD). More than 60 pathogenic mutations have been …

Objectives We report the clinical presentation and evolution of a case with a novel
Progranulin gene (GRN) mutation and non-fluent language disturbances at onset. Materials …