The trans-histone regulatory cross talk between H2BK123 ubiquitination (H2Bub1) and
H3K4 and H3K79 methylation is not fully understood. In this study, we report that the …

Regulation of Set1-COMPASS-mediated H3K4 methylation and Dot1-mediated H3K79
methylation by H2BK123 ubiquitination (H2Bub1) is an evolutionarily conserved trans …

Monoubiquitination of histone H2B on Lys 123 (H2BK123ub) is a transient histone
modification considered to be essential for establishing H3K4 and H3K79 trimethylation by …

The stimulation of trimethylation of histone H3 Lys4 (H3K4) by H2B monoubiquitination
(H2Bub) has been widely studied, with multiple mechanisms having been proposed for this …

Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional
elongation, chromatin conformation, as well as the regulation of specific histone H3 …

Histone Crosstalk: H2Bub and H3K4 Methylation Page 1 Histone Crosstalk: H2Bub and
H3K4 Methylation Luis M. Soares1 and Stephen Buratowski1,* 1Department of Biological …

The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …

Trimethylated histone H3 lysine 4 (H3K4) and H3K27 generally mark transcriptionally active
and repressive chromatins, respectively. In most cell types, these two modifications are …

Ubiquitylation of histone H2B at lysine 120 (H2B-Ub), a post-translational modification first
discovered in 1980, plays a critical role in diverse nuclear processes including the …

Abstract H2B ubiquitylation (H2Bub)-dependent H3K4 methylation is mediated by the
multisubunit Set1 complex (Set1C) in yeast, but precisely how Set1C subunits contribute to …