Advances in the biosynthesis, diversification, and hyperproduction of ganoderic acids in Ganoderma lucidum

P Bondzie-Quaye, MS Swallah, A Acheampong… - Mycological …, 2023 - Springer
Ganoderic acids (GA) are one of the important secondary metabolites acquired from
Ganoderma lucidum (G. lucidum) with a wide range of pharmacological activities and …

Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum

Y Du, L Tian, Y Wang, Z Li, Z Xu - Chinese Medicine, 2024 - Springer
Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both
medicine and food. Ganoderic acids (GAs), the distinctive triterpenoids found in the …

Current progress in the study on biosynthesis and regulation of ganoderic acids

L Shi, A Ren, D Mu, M Zhao - Applied microbiology and biotechnology, 2010 - Springer
Ganoderic acids (GAs) isolated from Ganoderma lucidum, which have shown remarkable
pharmacological activities and a variety of therapeutic effects on a number of human …

Profiling and Quantifying Differential Gene Transcription Provide Insights into Ganoderic Acid Biosynthesis in Ganoderma lucidum in Response to Methyl Jasmonate

A Ren, MJ Li, L Shi, DS Mu, AL Jiang, Q Han… - PloS one, 2013 - journals.plos.org
Ganoderma lucidum is a mushroom with traditional medicinal properties that has been
widely used in China and other countries in Eastern Asia. Ganoderic acids (GA) produced …

[HTML][HTML] The pharmacological effects of triterpenoids from Ganoderma lucidum and the regulation of its biosynthesis

S Chen - Advances in Biological Chemistry, 2020 - scirp.org
Ganoderma lucidum is a wildly used medicinal mushroom and has been used in East Asia
because of its health-benefit effects. G. lucidum contains various compounds with different …

Shedding light on the mechanisms underlying the environmental regulation of secondary metabolite ganoderic acid in Ganoderma lucidum using physiological and …

A Ren, L Shi, J Zhu, H Yu, A Jiang, H Zheng… - Fungal genetics and …, 2019 - Elsevier
The secondary metabolites of fungi are often produced at very low concentrations, and until
recently the regulatory mechanisms of secondary metabolite biosynthesis have been …

Genetic engineering of Ganoderma lucidum for the efficient production of ganoderic acids

JW Xu, JJ Zhong - Bioengineered, 2015 - Taylor & Francis
Ganoderma lucidum is a well-known traditional medicinal mushroom that produces
ganoderic acids with numerous interesting bioactivities. Genetic engineering is an efficient …

Effect of solid-medium coupled with reactive oxygen species on ganoderic acid biosynthesis and MAP kinase phosphorylation in Ganoderma lucidum

BJ You, WT Chang, KR Chung, YH Kuo… - Food research …, 2012 - Elsevier
Ganoderma lucidum is used as a functional food and medicinal mushroom in Asia.
Biosynthesis of its active ingredients, the ganoderic acids (GAs), together with signal …

Production of triterpenoids from Ganoderma lucidum: Elicitation strategy and signal transduction

L Gu, Y Zheng, D Lian, X Zhong, X Liu - Process Biochemistry, 2018 - Elsevier
Ganoderic triterpenoid (GT) is a promising anti-tumour constituent of Ganoderma lucidum.
GT accumulation occurs following stressors that include various elicitors or signalling …

Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum

AL Jiang, YN Liu, R Liu, A Ren, HY Ma, LB Shu… - International Journal of …, 2019 - mdpi.com
Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously
reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of …