Objectives Risk-of-bias assessment is a central component of systematic reviews, but little
conclusive empirical evidence exists on the validity of such assessments. In the context of …

Objective Risk-of-bias assessment is a central component of systematic reviews but little
conclusive empirical evidence exists on the validity of such assessments. In the context of …

This document updates the existing Agency for Healthcare Research and Quality (AHRQ)
Evidence-based Practice Center (EPC) Methods Guide for Effectiveness and Comparative …

Background Assessing the risk of bias in individual studies in a systematic review can be
done using individual components or by summarizing the study quality in an overall score …

Background Different tools exist for assessing risk of bias of intervention studies for
systematic reviews. We present a tool for assessing risk of bias across both randomized and …

Objectives To assess the reliability of the Cochrane Risk of Bias (ROB) tool between
individual raters and across consensus agreements of pairs of reviewers and examine the …

Objective To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews
(rather than in primary studies). Study Design and Setting We used four-stage approach to …

Background Systematic reviews of health interventions are increasingly incorporating
evidence outside of randomized controlled trials (RCT). While non-randomized study (NRS) …

Objectives To evaluate how often reproducible research practices, which allow others to
recreate the findings of studies, given the original data, are used in systematic reviews (SRs) …

Background Systematic reviews (SRs) are expected to critically appraise included studies
and privilege those at lowest risk of bias (RoB) in the synthesis. This study examines if and …