Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …
several important bacterial pathogens. The central element of these machines is the …
[HTML][HTML] In situ molecular architecture of the Salmonella type III secretion machine
Type III protein secretion systems have specifically evolved to deliver bacterially encoded
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …
Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …
Structure of a pathogenic type 3 secretion system in action
J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
High-resolution view of the type III secretion export apparatus in situ reveals membrane remodeling and a secretion pathway
C Butan, M Lara-Tejero, W Li, J Liu… - Proceedings of the …, 2019 - National Acad Sciences
Type III protein secretion systems are essential virulence factors for many important
pathogenic bacteria. The entire protein secretion machine is composed of several …
pathogenic bacteria. The entire protein secretion machine is composed of several …
A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion
EZ Guo, DC Desrosiers, J Zalesak, J Tolchard… - PLoS …, 2019 - journals.plos.org
Type III protein-secretion machines are essential for the interactions of many pathogenic or
symbiotic bacterial species with their respective eukaryotic hosts. The core component of …
symbiotic bacterial species with their respective eukaryotic hosts. The core component of …
The type III secretion injectisome
GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …
Common and distinct structural features of Salmonella injectisome and flagellar basal body
Bacterial pathogens use an injectisome to deliver virulence proteins into eukaryotic host
cells. The bacterial flagellum and injectisome export their component proteins for self …
cells. The bacterial flagellum and injectisome export their component proteins for self …
T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly
The bacterial injectisome is a syringe-shaped macromolecular nanomachine utilized by
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
many pathogenic Gram-negative bacteria, including the causative agents of plague, typhoid …
Molecular ruler determines needle length for the Salmonella Spi-1 injectisome
DH Wee, KT Hughes - … of the National Academy of Sciences, 2015 - National Acad Sciences
The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines:
the bacterial flagellum that enables cells to propel themselves through liquid and across …
the bacterial flagellum that enables cells to propel themselves through liquid and across …