Translational medicine pursues the conversion of scientific discovery into human health
improvement. It aims to establish strategies for diagnosis and treatment of diseases. Cancer …

Iodine-131-labeled monoiodohypericin (131I-Hyp) is a necrosis avid compound used as a
complementary anticancer agent. Herein, the biodistribution in rats with re-perfused partial …

Purpose To study whether formulation influences biodistribution, necrosis avidity and
tumoricidal effects of the radioiodinated hypericin, a necrosis avid agent for a dual-targeting …

Research on imaging contrast media over the last decades has led to the discovery of small
molecular necrosis-avid compounds (NACs) for potential applications in diagnosis of …

Objectives: To study the effect of co-injecting unlabelled hypericin (Hyp) on biodistribution,
necrosis uptake and tumour retention of iodine-123 or iodine-131 labelled hypericin …

Cancers are often with spontaneous or therapeutic necrosis that could be utilized as a
generic target for developing new treatments. The purpose of this study was to investigate …

Abstract Background Iodine-131 labeled hypericin (131 I-Hyp) has been utilized as a
necrosis-avid theragnostic tracer in a dual targeting pan-anticancer strategy called …

Hypericin is a necrosis avid agent useful for nuclear imaging and tumor therapy.
Protohypericin, with a similar structure to hypericin except poorer planarity, is the precursor …

Lung cancer is the leading cause of cancer-related death. About 80% of lung cancers are
non–small cell lung cancers (NSCLC). Radiotherapy is widely used in treatment of NSCLC …

Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes
a great hindrance in clinical application. The aim of this paper was to explore sodium …