Astrocytes are the major intracerebral source of macrophage inflammatory protein‐3α/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro

E Ambrosini, S Columba‐Cabezas, B Serafini… - Glia, 2003 - Wiley Online Library
Macrophage inflammatory protein‐3α/CCL20 is a recently identified chemokine that binds to
CCR6 and acts as a chemoattractant for memory/differentiated T‐cells, B‐cells, and …

Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia: implications for disease …

S Columba-Cabezas, B Serafini, E Ambrosini… - Journal of …, 2002 - Elsevier
Macrophage-derived chemokine (MDC/CCL22) and its receptor CCR4 have been
implicated in chronic inflammatory processes and in the homing of monocytes, Th2 cells and …

Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the …

S Columba‐Cabezas, BS Elena, AF Aloisi - Brain pathology, 2003 - Wiley Online Library
The simultaneous presence of dendritic, T‐and B‐cells in the central nervous system (CNS)
of mice with experimental autoimmune encephalomyelitis (EAE), a model for multiple …

Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis

A Elhofy, RW DePaolo, SA Lira, NW Lukacs… - Journal of …, 2009 - Elsevier
Chemokines are a superfamily of chemotactic cytokines that play an important role in
leukocyte trafficking and have been implicated as functional mediators of immunopathology …

Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell–cell communication

M Kanno, S Suzuki, T Fujiwara, A Yokoyama… - Journal of …, 2005 - Elsevier
There is growing evidence that chemokines play important roles in the immune surveillance
of central nervous system (CNS). In the CNS, microglia are primary immune effector cells …

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

RY Kim, AS Hoffman, N Itoh, Y Ao, R Spence… - Journal of …, 2014 - Elsevier
Abstract Chemokine (CC motif) ligand 2 (CCL2), initially identified as monocyte
chemoattractant protein-1 (MCP-1), recruits immune cells to the central nervous system …

The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis

K Moriguchi, K Miyamoto, N Tanaka, O Yoshie… - Journal of …, 2013 - Elsevier
Chemokine receptors (CCRs) play important roles in the pathogenesis of immune-mediated
diseases, as well as in normal immune response. We examined the role of CCR6 and CCR4 …

CCR 7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells

T Kuwabara, F Ishikawa, T Yasuda… - The Journal of …, 2009 - journals.aai.org
CCL19 and CCL21 are thought to be critical for experimental autoimmune
encephalomyelitis (EAE) induction, but their precise role is unknown. We examined the role …

CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function

EA Forde, RNE Dogan, WJ Karpus - Journal of neuroimmunology, 2011 - Elsevier
Chemokines and their receptors play a critical role in orchestrating the immune response
during experimental autoimmune encephalomyelitis (EAE). Expression of CCR4 and its …

CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons

L Fülle, N Offermann, JN Hansen, B Breithausen… - Glia, 2018 - Wiley Online Library
Chemokines are important signaling molecules in the immune and nervous system. Using a
fluorescence reporter mouse model, we demonstrate that the chemokine CCL17, a ligand of …