Aberrant DNA methylation reduces the developmental competence of mammalian somatic
cell nuclear transfer (SCNT) embryos. Thus, hypomethylation-associated drugs are …

Aberrant epigenetic reprogramming is known to be a major cause of inefficient somatic cell
nuclear transfer (SCNT) in pigs, and use of epigenetic modification agents, such as DNA …

Somatic cell nuclear transfer (SCNT) technology has been applied in the construction of
disease model, production of transgenic animals, therapeutic cloning, and other fields …

Somatic cell nuclear transfer (SCNT) derived embryos suffer from abnormal epigenetic
reprogramming, which handicaps pre-and postimplantation development. It was …

Aberration in DNA methylation is believed to be one of the major causes of abnormal gene
expression and inefficiency of somatic cell nuclear transfer (SCNT). RG108, a non …

Background/Aims: DNA methylation and histone modifications are essential epigenetic
marks that can significantly affect the mammalian somatic cell nuclear transfer (SCNT) …

Somatic cell nuclear transfer (SCNT) in mammalian cloning currently remains inefficient.
Incomplete or erroneous epigenetic reprogramming of specialized donor somatic nuclear …

DNA methylation reprogramming plays important roles in mammalian embryogenesis.
Mammalian somatic cell nuclear transfer (SCNT) embryos with reprogramming defects fail to …

Nuclear reprogramming induced by somatic cell nuclear transfer is an inefficient process,
and donor cell DNA methylation status is thought to be a major factor affecting cloning …

Faulty epigenetic reprogramming of somatic nuclei is thought to be the main reason for low
cloning efficiency by somatic cell nuclear transfer (SCNT). Histone deacetylase inhibitors …