We have previously shown that the glucose intolerance and the hyperglycemic state in the
GK rat, a new spontaneous model of non-insulin-dependent (type II) diabetes without …

In early 1988, a colony of GK rats was started in Paris with progenitors issued from F35 of
the original colony reported by Goto and Kakisaki. When studied longitudinally up to 8 mo …

Adult Goto-Kakisaki Wistar (GK) rats exhibit a spontaneous non-insulin-dependent diabetes
characterized by impaired glucose-induced insulin secretion, decreased beta-cell mass …

It is unclear whether reported histopathological changes in the endocrine pancreas of the
GK rat (a spontaneous model of non-insulin-dependent diabetes) are related to the …

In normal (N), 3-days starved (S), and streptozotocin-treated (65 mg/kg) 3-days diabetic (D)
rats we examined the in vivo dose-response relationship between plasma insulin levels vs …

We have studied the structure and function of the partially purified insulin receptors from liver
and skeletal muscle in a rat model of severe chronic uremia. 125I-insulin binding was higher …

Spontaneously diabetic nonobese GK rats exhibit high basal plasma glucose and insulin
levels and a poor insulin secretory response to glucose. We studied insulin biosynthesis …

Insulin resistance is accentuated during periods of poor metabolic control in human non-
insulin-dependent diabetes mellitus. The role of hyperglycemia in this suppression of insulin …

This study was undertaken to characterize the insulin resistance and the mechanism thereof
caused by chronic hyperinsulinemia produced in dogs by surgically diverting the veins of the …

A bolus injection of insulin dose-dependently reduced plasma glucose levels in genetically
diabetic (db/db) mice and their normoglycaemic littermates (+/+ mice) aged 5, 8 and 12 …