Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
O Scudiero, S Galdiero, M Cantisani… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Human beta-defensins (hBDs) are antimicrobial peptides of human innate immunity. The
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …
antibacterial activities of hBDs 1, 2, and 4 but not the activity of hBD3 are impaired by high …
Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines
Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are
thus prime candidates as therapeutic agents directed against infective diseases. Based on …
thus prime candidates as therapeutic agents directed against infective diseases. Based on …
Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity
JRC García, A Krause, S Schulz… - The FASEB …, 2001 - Wiley Online Library
ABSTRACT β‐Defensins are antibiotic peptides involved in host defense at the epithelial
surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have been …
surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have been …
Bacterial expression and antibiotic activities of recombinant variants of human β-defensins on pathogenic bacteria and M. tuberculosis
L Corrales-Garcia, E Ortiz… - Protein expression and …, 2013 - Elsevier
Five variants of human β-defensins (HBDs) were expressed in Escherichia coli using two
vector systems (pET28a (+) and pQE30) with inducible expression by IPTG. The last vector …
vector systems (pET28a (+) and pQE30) with inducible expression by IPTG. The last vector …
Antimicrobial characterization of human β-defensin 3 derivatives
DM Hoover, Z Wu, K Tucker, W Lu… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
Human defensins
JJ Schneider, A Unholzer, M Schaller… - Journal of molecular …, 2005 - Springer
Antimicrobial peptides are small, cationic, amphiphilic peptides of 12–50 amino acids with
microbicidal activity against both bacteria and fungi. The eukaryotic antimicrobial peptides …
microbicidal activity against both bacteria and fungi. The eukaryotic antimicrobial peptides …
Human β-defensin 2 and β-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules
S Jung, J Mysliwy, B Spudy, I Lorenzen… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Despite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) kills
Staphylococcus aureus with a 4-to 8-fold higher efficiency than human β-defensin 2 (HBD2) …
Staphylococcus aureus with a 4-to 8-fold higher efficiency than human β-defensin 2 (HBD2) …
In vitro bactericidal activity of human β-defensin 2 against nosocomial strains
JG Routsias, P Karagounis, G Parvulesku, NJ Legakis… - Peptides, 2010 - Elsevier
Human β-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune
system that serves as antimicrobial molecule. We determined the bactericidal activity of …
system that serves as antimicrobial molecule. We determined the bactericidal activity of …
Structure− activity relation of human β-defensin 3: influence of disulfide bonds and cysteine substitution on antimicrobial activity and cytotoxicity
E Klüver, S Schulz-Maronde, S Scheid, B Meyer… - Biochemistry, 2005 - ACS Publications
Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
The solution structures of the human β-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus
DJ Schibli, HN Hunter, V Aseyev, TD Starner… - Journal of Biological …, 2002 - ASBMB
The three human β-defensins, HBD1–3, are 33–47-residue, cationic antimicrobial proteins
expressed by epithelial cells. All three proteins have broad spectrum antimicrobial activity …
expressed by epithelial cells. All three proteins have broad spectrum antimicrobial activity …