Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety
DM Klinman, S Kamstrup, D Verthelyi, I Gursel… - Springer seminars in …, 2000 - Springer
The risks of using CpG ODN to improve the host's innate or adaptive immune response must
be considered. While the immunostimulatory effects of CpG DNA have been studied using …
be considered. While the immunostimulatory effects of CpG DNA have been studied using …
Innate immune responses induced by classes of CpG oligodeoxynucleotides in ovine lymph node and blood mononuclear cells
JS Booth, AK Nichani, P Benjamin, A Dar… - Veterinary immunology …, 2007 - Elsevier
CpG ODN signal through Toll-like receptor 9 (TLR9) and trigger a cascade of events that
lead to activation of innate and adaptive immune responses. Our current understanding of …
lead to activation of innate and adaptive immune responses. Our current understanding of …
Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs
H ZHAO, SH CHENG, NS YEW - Antisense and Nucleic Acid Drug …, 2000 - liebertpub.com
The DNA of bacteria and many viruses contain unmethylated CpG dinucleotides in particular
sequence contexts that activate vertebrate immune cells. A subset of these CpG motifs was …
sequence contexts that activate vertebrate immune cells. A subset of these CpG motifs was …
In vitro activation of chicken leukocytes and in vivo protection against Salmonella enteritidis organ invasion and peritoneal S. enteritidis infection-induced mortality in …
H He, VK Lowry, CL Swaggerty… - FEMS Immunology & …, 2005 - academic.oup.com
Abstract Unmethylated CpG oligodinucleotides (CpG-ODN) flanked by specific bases found
in bacterial DNA are known to stimulate innate immune responses. In this study, synthetic …
in bacterial DNA are known to stimulate innate immune responses. In this study, synthetic …
CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections.
AM Harandi, J Holmgren - Current opinion in investigational drugs …, 2004 - europepmc.org
Recent advances in immunology reveal that vertebrate innate immune systems use pattern-
recognition receptors, of which the best characterized is the toll-like receptor (TLR) family, to …
recognition receptors, of which the best characterized is the toll-like receptor (TLR) family, to …
Secondary structures in CpG oligonucleotides affect immunostimulatory activity
ER Kandimalla, L Bhagat, YP Cong, RK Pandey… - Biochemical and …, 2003 - Elsevier
Oligodeoxynucleotides containing CpG dinucleotides in specific sequence contexts activate
the vertebrate immune system. Our previous studies showed that the 5′-end of a CpG …
the vertebrate immune system. Our previous studies showed that the 5′-end of a CpG …
CpG DNA as a vaccine adjuvant
DM Klinman - Expert review of vaccines, 2003 - Taylor & Francis
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold …
Identification of CpG oligodeoxynucleotide sequences that induce IFN-γ production in canine peripheral blood mononuclear cells
K Kurata, A Iwata, K Masuda, M Sakaguchi… - Veterinary immunology …, 2004 - Elsevier
Oligodeoxynucleotides containing the cytosine-phosphate-guanine (CpG) motif (CpG-
ODNs) have been shown to induce TH1 immune responses in animals. Since the …
ODNs) have been shown to induce TH1 immune responses in animals. Since the …
Phosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG …
AH Dalpke, S Zimmermann, I Albrecht, K Heeg - Immunology, 2002 - Wiley Online Library
Bacterial DNA and oligonucleotides (ODN) containing CpG‐motifs strongly activate cells of
the immune system. Accordingly CpG‐DNA is a powerful adjuvant in vaccination protocols …
the immune system. Accordingly CpG‐DNA is a powerful adjuvant in vaccination protocols …
Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
T Shimosato, M Tohno, T Sato… - Animal Science …, 2009 - Wiley Online Library
Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are
potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG …
potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG …