Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Perioperative myocardial ischemia occurs in 20-40% of patients at risk for
cardiac morbidity and is associated with a ninefold increase in risk of cardiac morbidity …

Background There is a belief that clonidine may be effective in reducing perioperative
myocardial ischemic events, although the results of several trials are conflicting. The aim of …

Clonidine may have beneficial effects in patients undergoing major surgery. We enrolled
156 patients having elective CABG surgery in a double-blind, randomized trial. Patients …

We studied 61 patients undergoing elective major non-cardiac surgery in a randomized,
double-blind, placebo-control clinical trial to test the hypothesis that the addition of clonidine …

Background Most new perioperative myocardial ischemic episodes occur in the absence of
hypertension or tachycardia. The ability of alpha 2-adrenoceptor agonists to inhibit central …

The purpose of this study was to determine if clonidine reduces myocardial ischemia or
alters anesthetic requirement and perioperative hemodynamic parameters during coronary …

Study objective A place for clonidine has been suggested for many indications in
perioperative medicine. The aim of this systematic review and these meta-analyses is to …

In this prospective study, we evaluated whether high thoracic epidural anesthesia (TEA) or
IV clonidine, in addition to general anesthesia, affects the cardiopulmonary bypass-and …

The utility of clonidine for hypertensive patients presenting for major vascular procedures
remains debatable. Twenty-one hypertensive patients presenting for aortic surgery were …