DNA repair pathways have long been recognized as important in protecting the genome
from damage caused by endogenous and exogenous DNA damaging agents. However, the …

Redox reactions are known to regulate many important cellular processes. In this review, we
focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA …

The DNA base excision-repair pathway is responsible for the repair of DNA damage caused
by oxidation/alkylation and protects cells against the effects of endogenous and exogenous …

The heterogeneity of most cancers diminishes the treatment effectiveness of many cancer-
killing regimens. Thus, treatments that hold the most promise are ones that block multiple …

This chapter focuses on APE1 (AP endonuclease or redox factor 1; APE1/Ref-1, Ref-1 or
APE1), which has multiple functions in DNA repair, transcriptional regulation, and RNA …

Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …

With our growing understanding of the pathways involved in cell proliferation and signaling,
targeted therapies, in the treatment of cancer are entering the clinical arena. New and …

Discovered as a DNA repair protein, Ape1 has been associated with other functions, notably
redox regulation of transcription factors (Ref1 activity). Because deletion of the mouse gene …

Abstract APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a
multifunctional protein possessing both DNA repair and transcriptional regulatory activities …

APE1 is an essential DNA repair protein that also possesses the ability to regulate
transcription. It has a unique cysteine residue C65, which maintains the reduce state of …