Tumor metastasis is not only a sign of disease severity but also a major factor causing
treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms …

Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …

Tumors showing evidence of epithelial-to-mesenchymal transition (EMT) have been
associated with metastasis, drug resistance, and poor prognosis. Heterogeneity along the …

Simple Summary The PI3K/AKT signaling pathway plays critical roles in regulating a series
of cellular changes to promote tumor development and progression. The cytoskeletal …

Epithelial to mesenchymal transition (EMT) is a programme defined in epithelial cells and
recognized as playing a critical role in cancer progression. Although melanoma is not a …

The role of PI3K in cancer has been well established, and mutations of PIK3CA, the gene
coding for catalytic subunit p110α of PI3K, are found in approximately 30% human cancers …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Aims and background The PI3 kinase signalling pathway is now accepted as being at least
as important as the ras-MAP kinase pathway in cell survival and proliferation, and hence its …

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth,
survival, motility, and metabolism. This pathway is activated by several different mechanisms …