The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Emerging insights into cellular senescence highlight the relevance of senescence in
musculoskeletal disorders, which represent the leading global cause of disability. Cellular …

Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic
inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and …

A gradual decline in skeletal muscle mass and function is closely tied to increased mortality
and disease risk during organismal aging. Exercise training is the most effective way to …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …

The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

Musculoskeletal ageing and its associated diseases are major contributors to the loss of
independence and reduced quality of life in older people. Several recent studies indicate …

Aging of an organism is associated with the functional decline of tissues and organs, as well
as a sharp decline in the regenerative capacity of stem cells. A prevailing view holds that the …

Cellular senescence is a state of cell cycle arrest induced by several forms of metabolic
stress. Senescent cells accumulate with advancing age and have a distinctive phenotype …

Ageing is an irreversible and inevitable biological process and a significant risk factor for the
development of various diseases, also affecting the musculoskeletal system, resulting from …