Cancer has recently been identified as the leading cause of mortality worldwide. Several
conventional treatments and cytotoxic immunotherapies have been developed and made …

Immunotherapy of cancer had its early beginnings in the times when the elements of the
immune system were still poorly characterized. However, with the progress in molecular …

Chimeric antigen receptor-modified T cells (CAR-T) have emerged as a new modality for
cancer immunotherapy due to their potent efficacy against terminal cancers. CAR-Ts are …

Chimeric antigen receptor (CAR) therapy is a promising modality for the treatment of
advanced cancers that are otherwise incurable. During the last decade, different centers …

Over the last decade, the emergence of several novel therapeutic approaches has changed
the therapeutic perspective of human malignancies. Adoptive immunotherapy through …

Although tremendous advancements in cancer therapy over the last several years, cancer
still is a complex illness to cure. Traditional cancer treatments, including chemotherapy …

CD4+ and CD8+ T lymphocytes are powerful components of adaptive immunity, which
essentially contribute to the elimination of tumors. Due to their cytotoxic capacity, T cells …

The use of chimeric antigen receptor (CAR)-modified T cells is a promising approach for
cancer immunotherapy. These genetically modified receptors contain an antigen-binding …

Background: Cancer is one of the leading causes of death worldwide. Over the years, a
number of conventional cytotoxic approaches for neoplastic diseases has been developed …

Advances in the development of immunotherapies have offered exciting new options for the
treatment of malignant diseases that are refractory to conventional cytotoxic …