The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor

R Ko, H Kenmotsu, Y Hisamatsu, H Akamatsu… - International journal of …, 2015 - Springer
Background It is unclear whether there is a difference in the effect of gefitinib treatment
between patients with postoperative recurrent non-small cell lung cancer (NSCLC) and …

Gefitinib treatment in patients with postoperative recurrent non-small-cell lung cancer harboring epidermal growth factor receptor gene mutations

Y Yokoyama, M Sonobe, T Yamada, M Sato… - International journal of …, 2015 - Springer
Background The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib
is an effective treatment for recurrent or advanced lung cancer harboring EGFR gene …

Impact of EGFR-tyrosine kinase inhibitors on postoperative recurrent non-small-cell lung cancer harboring EGFR mutations

S Igawa, S Ryuge, M Ichinoe, H Nakashima… - Oncology research and …, 2017 - karger.com
Background: It is unclear whether there is a difference in the efficacy of treatment by
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) between patients …

Prognostic factors for gefitinib-treated postoperative recurrence in non-small cell lung cancer

J Okami, K Taniguchi, M Higashiyama, J Maeda, K Oda… - Oncology, 2008 - karger.com
Abstract Background and Objectives: The association between epidermal growth factor
receptor (EGFR) mutations and response to EGFR tyrosine kinase inhibitor (TKI) has been …

The characteristics and failure pattern of gefitinib responders with postoperative recurrence of pulmonary adenocarcinoma

F Shoji, T Yano, I Yoshino, D Mori, F Yamasaki… - European Journal of …, 2008 - Elsevier
AIMS: Gefitinib shows prominent anti-tumor activity against advanced or recurrent non-small
cell lung cancer (NSCLC). However, most gefitinib-responsive patients ultimately relapse …

Effect of gefitinib on the survival of patients with recurrence of lung adenocarcinoma after surgery: a retrospective case-matching cohort study

T Katayama, K Matsuo, T Kosaka, T Sueda, Y Yatabe… - Surgical Oncology, 2010 - Elsevier
BACKGROUND: Patients with lung adenocarcinoma who carry epidermal growth factor
receptor (EGFR) gene mutations respond remarkably well to EGFR tyrosine kinase inhibitor …

Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non–small-cell lung cancer with …

T Mitsudomi, T Kosaka, H Endoh, Y Horio… - Journal of Clinical …, 2005 - ascopubs.org
Purpose To evaluate the relationship between mutations of the epidermal growth factor
receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent …

Surgical resection after gefitinib treatment in patients with lung adenocarcinoma harboring epidermal growth factor receptor gene mutation

K Takamochi, K Suzuki, H Sugimura, K Funai, H Mori… - Lung Cancer, 2007 - Elsevier
Gefitinib is the first approved epidermal growth factor receptor (EGFR) tyrosine kinase
inhibitor (TKI) for the treatment of patients with advanced non-small cell lung cancer …

Clinical usefulness of gefitinib for non-small-cell lung cancer with a double epidermal growth factor receptor mutation

T Oikawa, T Ohira, K Otani… - Molecular and …, 2015 - spandidos-publications.com
The aim of this study was to investigate whether the pattern of epidermal growth factor
receptor (EGFR) gene mutations affects sensitivity to gefitinib treatment. We investigated 44 …

Impact of the epidermal growth factor receptor mutation status on the post-recurrence survival of patients with surgically resected non-small-cell lung cancer

T Takenaka, M Takenoyama… - European Journal of …, 2015 - academic.oup.com
OBJECTIVES The impact of epidermal growth factor receptor (EGFR) status and the use of
EGFR-tyrosine kinase inhibitor (EGFR-TKI) therapy have not been well discussed only in …