Multiple sclerosis-related fatigue: the role of impaired corticospinal responses and heightened exercise fatigability

KD Coates, SJ Aboodarda, RL Krüger… - Journal of …, 2020 - journals.physiology.org
It is unclear whether motor fatigability and perceived fatigue share a common
pathophysiology in people with multiple sclerosis (PwMS). This cross-sectional investigation …

How is neuromuscular fatigability affected by perceived fatigue and disability in people with multiple sclerosis?

N Royer, K Coates, SJ Aboodarda… - Frontiers in …, 2022 - frontiersin.org
Whereas fatigue is recognized to be the main complaint of patients with multiple sclerosis
(PwMS), its etiology, and particularly the role of resistance to fatigability and its interplay with …

A qualitative review of the neurophysiological underpinnings of fatigue in multiple sclerosis

A Yusuf, L Koski - Journal of the neurological sciences, 2013 - Elsevier
Fatigue is debilitating in multiple sclerosis (MS) and may have multiple causes. Recent
investigations into objectively measurable correlates of fatigue have used transcranial …

Fatigue in multiple sclerosis: general and perceived fatigue does not depend on corticospinal tract dysfunction

L Mordillo-Mateos, V Soto-Leon… - Frontiers in …, 2019 - frontiersin.org
Background: Multiple sclerosis (MS) is an autoimmune disorder of the CNS in which
inflammation, demyelination, and axonal damage of the central nervous system coexist …

The pathophysiology of motor fatigue and fatigability in multiple sclerosis

R Patejdl, UK Zettl - Frontiers in Neurology, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a heterogeneous immune mediated disease of the central nervous
system (CNS). Fatigue is one of the most common and disabling symptom of MS. It interferes …

Fatigue perceived by multiple sclerosis patients is associated with muscle fatigue

A Steens, A de Vries, J Hemmen… - … and neural repair, 2012 - journals.sagepub.com
Background. Fatigue is a debilitating symptom in multiple sclerosis (MS). Previous studies
showed no association between fatigue as perceived by the patient and physiological …

Neurostructural and neurophysiological correlates of multiple sclerosis physical fatigue: systematic review and meta-analysis of cross-sectional studies

PM Ellison, S Goodall, N Kennedy, H Dawes… - Neuropsychology …, 2022 - Springer
Fatigue is one of the most debilitating symptoms for people with multiple sclerosis (PwMS).
By consolidating a diverse and conflicting evidence-base, this systematic review and meta …

Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: a combined electrophysiological and neuroimaging study

A Steens, DJ Heersema, NM Maurits, RJ Renken… - Neuroimage, 2012 - Elsevier
Increased sense of fatigue is an important and conspicuous symptom in multiple sclerosis
(MS). Muscle fatigue is associated with increased sense of fatigue in MS (Steens et al …

Fatigued patients with multiple sclerosis have impaired central muscle activation

AK Andreasen, J Jakobsen, T Petersen… - Multiple Sclerosis …, 2009 - journals.sagepub.com
Background The pathogenesis of fatigue in multiple sclerosis (MS) is poorly understood.
Objective To elucidate the role of central motor activation we hypothesized that patients with …

Potential pathophysiological pathways that can explain the positive effects of exercise on fatigue in multiple sclerosis: a scoping review

M Langeskov-Christensen, EJ Bisson… - Journal of the …, 2017 - Elsevier
Background Fatigue is one of the most common and most disabling symptoms of multiple
sclerosis (MS). It is a multidimensional and complex symptom with multifaceted origins …