KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates
signaling cascades linked to biological processes such as proliferation, differentiation …

PURPOSE: Activation of the KIT tyrosine kinase by somatic mutation has been documented
in a number of human malignancies, including gastrointestinal stromal tumor (GIST) …

Introduction: Mutated forms of the receptor tyrosine kinase c-KIT are “drivers” in several
cancers and are attractive targets for therapy. While benefits have been obtained from use of …

In 2002, we published a review in Journal of Clinical Oncology examining the potential of
KIT inhibition to treat advanced cancer. 1 At that time, imatinib was the first and only US …

Kit a type III receptor tyrosine kinase, along with its ligand the stem cell factor, play a critical
role in normal cell growth, differentiation, development and survival. Ligand independent …

The Kit receptor tyrosine kinase is a transmembrane receptor that is expressed in a variety of
different tissues and mediates pleiotropic biological effects through its ligand stem cell factor …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

Receptor tyrosine kinases play an important role in many cellular processes, and their
dysregulation leads to diseases, most importantly cancer. One such receptor tyrosine kinase …

Mutation of KIT receptor tyrosine kinase at residue D816 results in ligand-independent
constitutive kinase activity. This mutation occurs in most patients with mastocytosis, a …

Mutations in the proto-oncogene c-kit, including point mutations, deletions, or duplications in
the negative regulatory juxtamembrane (JM) domain or point mutations in the catalytic …