Progressive fibrosis of organs, such as the liver, the kidney, or the lung, is the basis of
mechanistically related disorders that are major causes of morbidity and mortality. As keloids …

Thirty-five years ago, Sies and colleagues insightfully described the universal phenomenon
that the generation of reactive oxygen species could modify macromolecules in living …

Activated hepatic stellate cells (HSCs) and myofibroblasts are the main producers of
extracellular matrix (ECM) proteins that form the fibrotic tissue that leads to hepatic fibrosis …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Significance: Enhanced levels of reactive oxygen species (ROS) have been associated with
different disease states. Most attempts to validate and exploit these associations by chronic …

During the past decades, it became obvious that reactive oxygen species (ROS) exert a
multitude of biological effects covering a wide spectrum that ranges from physiological …

Reactive oxygen and nitrogen species (ROS and RNS) are produced by metabolism of
normal cells. However, in liver diseases, redox is increased thereby damaging the hepatic …

Generation of reactive oxygen species (ROS) by plasma membrane–localized NADPH
oxidase (Nox 2) is a major mechanism of cell signaling associated with activation of the …

The intestinal epithelium sits at the interface between an organism and its luminal
environment, and as such is prone to oxidative damage induced by luminal oxidants …

Macrophages are phagocytic cells that produce and release reactive oxygen species (ROS)
in response to phagocytosis or stimulation with various agents. The enzyme responsible for …